The main characters in many Spanish novels of the Golden Age travel and acquire knowledge during their journeys. In the present paper I study the relationship between their spacial movements and their learning processes. In picaresque novels such as ‚Lazarillo de Tormes‘ (1554), ‚Guzmán de Alfarache‘ (1599 & 1604) or Buscón (1526) the life of the rogue is not only a metaphorical journey. These antiheroes move through Spain and Europe and, on their way, they learn to survive gaining new skills like begging, cheating and swindling. Francisco Delicados’ ‚Retrato de la Lozana Andaluza‘ (1528) is in a certain sense a precursor of the picaresque novel. It presents an itinerant female protagonist. She makes her living in Renaissance Rome by means of her medical and pharmaceutical expertise and through her acquaintance with the human body and soul. As in the historic case of the physician Andrés Laguna, Lozana’s knowledge and her travelling infringe on the borders of what is licit because of her condition as a converted Jew (and as a woman).